Perilla (Perilla frutescens) leaf extract inhibits SARS-CoV-2 via direct virus inactivation
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چکیده
منابع مشابه
Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway.
In this study, isoegomaketone(IK) was isolated from Perilla frutescens(L.), a Chinese herbal. The effects of IK were examined by cell viability assay, colony formation assay, xenograft tumor assay and western blotting in HCC cells. We found that IK inhibited cell viability, and its administration decreased tumor volume and weight profoundly. The presence of IK(10 nmol/l) produced a dramatic dec...
متن کاملAnti-hyperglycemic effects and signaling mechanism of Perilla frutescens sprout extract
BACKGROUND/OBJECTIVES Perilla frutescens (L.) Britton var. (PF) sprout is a plant of the labiate family. We have previously reported the protective effects of PF sprout extract on cytokine-induced β-cell damage. However, the mechanism of action of the PF sprout extract in type 2 diabetes (T2DM) has not been investigated. The present study was designed to study the effects of PF sprout extract a...
متن کاملSuppressive effects of Perilla frutescens on mesangioproliferative glomerulonephritis in rats.
Leaves of Perilla frutescens var. crispa DECNE. (perilla, Labiatae) are used as a garnishing vegetable in East Asian countries as well as an herbal medicine prescribed in Kampo medicines such as Saiboku-to. A previous in vitro study revealed that a decoction of perilla leaves inhibits the proliferation of murine-cultured mesangial cells. In the present study, we evaluated the in vivo anti-proli...
متن کاملAlleviation of atopic dermatitis-related symptoms by Perilla frutescens Britton.
To ascertain whether an aqueous fraction of Perilla frutescens Britton (PfB/af) has advantageous anti-atopic dermatitis activity, we used a 2,4-dinitrofluorobenzene (DNFB)-induced animal model of atopic dermatitis symptoms to investigate the effects of the extract. We performed an ear swelling assay by comparing thickness of the DNFB-induced ear, and measured the numbers of eosinophils as well ...
متن کاملRapid Identification of Aldose Reductase Inhibitory Compounds from Perilla frutescens
The ethyl acetate (EtOAc) soluble fraction of methanol extracts of Perilla frutescens (P. frutescens) inhibits aldose reductase (AR), the key enzyme in the polyol pathway. Our investigation of inhibitory compounds from the EtOAc soluble fraction of P. frutescens was followed by identification of the inhibitory compounds by a combination of HPLC microfractionation and a 96-well enzyme assay. Thi...
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ژورنال
عنوان ژورنال: Biomedical Journal
سال: 2021
ISSN: 2319-4170
DOI: 10.1016/j.bj.2021.01.005